3-Aminopyridine → 8-(3-Pyridyl)-8-azaspiro[4,5]decan-7,9-dione
反応式
[CH2:1]1[CH2:5][C:4]2([CH2:12][C:10](=[O:11])[O:9][C:7](=O)[CH2:6]2)[CH2:3][CH2:2]1.[NH2:13][C:14]1[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=1>C1(C)C(C)=CC=CC=1>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([N:13]2[C:7](=[O:9])[CH2:6][C:4]3([CH2:3][CH2:2][CH2:1][CH2:5]3)[CH2:12][C:10]2=[O:11])[CH:15]=1参加物
4
実験手順
The starting material is prepared as follows. The mixture of 16.8 g of 3,3-tetramethyleneglutaric anhydride, 9.4 g of 3-aminopyridine and 225 ml of xylene is stirred and refluxed for 48 hours while collecting the water formed. After cooling in the refrigerator the precipitate obtained is filtered off and recrystallized from 300 ml ethanol-hexane, to yield the 8-(3-pyridyl)-8-azaspiro[4,5]decan-7,9-dione melting at 153°-154°.
後処理
- customThe starting material is prepared
- temperaturerefluxed for 48 hours
- customwhile collecting the water
- customformed
- temperatureAfter cooling in the refrigerator the precipitate
- customobtained
- filtrationis filtered off
- customrecrystallized from 300 ml ethanol-hexane
出典と根拠
- ORDレコード
- ord-2f1c898da73c49e6806d3c06b02b64ab
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04255429
反応ノート
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