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Chloroacetic Acid → S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Chloroacetic Acid | HCID 300 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Bucillamine | HCID 656604 | — |
| 溶媒 | Potassium Carbonate | HCID 11430 | — |
| 生成物 | S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine | HCID 12876168 | 194.5% |
反応手順
N-(2-Mercapto-2-methylpropanoyl)-L-cysteine (11.2 g, 0.05 mol) is dissolved in 1 M potassium carbonate and monochloroacetic acid (11.3 g, 0.12 mol) and potassium iodide (1.0 g) are added. The mixture is stirred overnight at room temperature under a nitrogen atmosphere and acidified with 6 N hydrochloric acid. Sodium chloride is added and the mixture is extracted with ethyl acetate. The organic layer is washed with saturated sodium chloride solution, dried and concentrated to dryness to yield 16.5 g (97.2%) of S-carboxymethyl-N-(2-carboxymethylthio-2-methylpropanoyl)-L-cysteine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04255446 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-44272a91e41947378530daad8def6fc9 |
| 出典メモ | uspto-grants-1981_03 |