Hydrochloric Acid → N-2-methyl-2-(methylthio)propanoyl-L-cysteine
反応式
[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[CH3:8][C:9]([S:14][CH3:15])([CH3:13])[C:10](Cl)=[O:11].Cl>C(=O)([O-])[O-].[K+].[K+]>[CH3:8][C:9]([S:14][CH3:15])([CH3:13])[C:10]([NH:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4])=[O:11]参加物
5
反応条件
- 温度
- 0 °C
実験手順
L-Cysteine (7.1 g) is dissolved in 88 ml of 2 M potassium carbonate and 7.5 g of 2-methyl-2-(methylthio)propanoyl chloride [b.p. 78° C. (37 mmHg)] is added dropwise while stirring under a nitrogen atmosphere at 0° C. After the addition, the mixture is stirred overnight at room temperature. The mixture is acidified with hydrochloric acid and the obtained crystals are separated by filtration and dried to yield 10.4 g (89.8%) of the titled compound.
後処理
- additionAfter the addition
- stirringthe mixture is stirred overnight at room temperature
- customthe obtained crystals are separated by filtration
- customdried
出典と根拠
- ORDレコード
- ord-1ca328e86dbf4115a5c3fbcde3584ea3
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04255446
反応ノート
読み込み中…