Hydrazine → N-amino-2-piperidylacetamide

HRID 1272975ノート

反応式

HRID 1272975 の反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][C:8]([O:10]C)=O.[NH2:12][NH2:13]>C(O)C>[NH2:12][NH:13][C:8](=[O:10])[CH2:7][CH:2]1[CH2:3][CH2:4][CH2:5][CH2:6][NH:1]1

参加物

4

反応物 2

HCID 9321HydrazineHCID 5214606Methyl piperidin-2-ylacetate

生成物 1

HCID 12587996N-amino-2-piperidylacetamide

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of methyl 2-piperidylacetate (1.082 mL, 5.84 mmol) in 1 mL of anhydrous ethanol was added anhydrous hydrazine (0.283 mL, 5.84 mmol). The solution was heated to reflux temperature overnight. The solvent was then removed under reduced pressure and the product was isolated as a gummy white solid in a quantitative yield and was used without further purification: ES-MS (m/z) 158 [M+H]+.

後処理

  1. temperatureThe solution was heated
  2. temperatureto reflux temperature overnight
  3. customThe solvent was then removed under reduced pressure
  4. customthe product was isolated as a gummy white solid in a quantitative yield
  5. customwas used without further purification

出典と根拠

ORDレコード
ord-e124249dffc94b568ce894a982876f22
出典データセット
uspto-grants-2007_04
特許番号
US07208513B2

反応ノート

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