化工社化工社 化学情報印刷レポート · 研究参考用
1-Methylthio-1-methylamino-2-nitroethylene → Desmethylranitidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Methylthio-1-methylamino-2-nitroethylene | HCID 123549 | — |
| 反応物 | 5-[[(2-Aminoethyl)thio]methyl]-N-methyl-2-furanmethanamine | HCID 20209492 | — |
| 生成物 | Desmethylranitidine | HCID 163116 | — |
反応手順
A mixture of 2-[[[5-(methylamino)methyl-2-furanyl]methyl]thio]ethanamine (0.9 g) and N-methyl-1-methylthio-2-nitro-etheneamine was heated at 100°-120° for 30 mins under water pump pressure. The residue was purified by column chromatography (silica/methanol: 0.88 ammonia) to give N-[2-[[[5-(methylamino)methyl-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine which was crystallised from acetonitrile m.p. 106°-108° (0.65 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04255440 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-bcb94db76b4442c5b7791ef685e693ea |
| 出典メモ | uspto-grants-1981_03 |