Hydrochloric Acid → 5-(2-Fluoro-6-methyl-pyridin-3-yl)-1H-pyrimidine-2,4-dione hydrochloride
反応式
[F:1][C:2]1[C:7]([C:8]2[C:9]([O:16]C)=[N:10][C:11]([O:14]C)=[N:12][CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1.[ClH:19]>O1CCOCC1>[ClH:19].[F:1][C:2]1[C:7]([C:8]2[C:9](=[O:16])[NH:10][C:11](=[O:14])[NH:12][CH:13]=2)=[CH:6][CH:5]=[C:4]([CH3:18])[N:3]=1参加物
4
実験手順
5-(2-Fluoro-6-methyl-pyridin-3-yl)-2,4-dimethoxy-pyrimidine (Prep114, 691 mg, 2.76 mmol) was dissolved in 4M HCl in dioxane solution (7 ml). After refluxing the reaction mixture for 45 minutes, the solvent was removed under vacuum to give 667 mg of the title compound (93% yield)
後処理
- temperatureAfter refluxing the reaction mixture for 45 minutes
- customthe solvent was removed under vacuum
出典と根拠
- ORDレコード
- ord-3fb63e5718eb421b975c24ab94c9dd0a
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07727988B2
反応ノート
読み込み中…