Ammonia → 7-Sulfamoyl-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid

HRID 127395

反応式

HRID 127395 の反応式
[NH3:1].Cl[S:3]([C:6]1[CH:7]=[C:8]([C:16]([OH:18])=[O:17])[C:9]2[O:14][CH2:13][CH2:12][O:11][C:10]=2[CH:15]=1)(=[O:5])=[O:4]>O>[S:3]([C:6]1[CH:7]=[C:8]([C:16]([OH:18])=[O:17])[C:9]2[O:14][CH2:13][CH2:12][O:11][C:10]=2[CH:15]=1)(=[O:5])(=[O:4])[NH2:1]

参加物

4

反応物 2

HCID 222AmmoniaHCID 64553167-(Chlorosulphonyl)-2,3-dihydro-1,4-benzodioxin-5-carboxylic acid

生成物 1

HCID 205447607-Sulfamoyl-2,3-dihydro-1,4-benzodioxine-5-carboxylic acid収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

209 g of 34% ammonia and 97 g of 7-chlorosulfonyl-1,4-benzodioxane-5-carboxylic acid were introduced into a balloon flask provided with an agitator and a thermometer at a temperature of 5°-10° C. The mixture was agitated at ambient temperature and then the precipitate was dissolved in 415 cm3 of water. The solution was filtered and treated with 140 cm3 of concentrated hydrochloric acid. The crystals were dried off, washed with water and dried. 78 g of 7-sulfamoyl-1,4-benzodioxane-5-carboxylic acid were obtained (M.P.: 272°-274° C.; yield: 87%).

後処理

  1. customprovided with an agitator
  2. customat a temperature of 5°-10° C
  3. filtrationThe solution was filtered
  4. additiontreated with 140 cm3 of concentrated hydrochloric acid
  5. customThe crystals were dried off
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-59290608f20644e7b3c71e10fb880512
出典データセット
uspto-grants-1981_03
特許番号
US04255580

関連ノート

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