2-(dimethylamino)-4-(trifluoromethyl)-6H-1,3-oxazin-6-one → {{5-[3,6-Dihydro-2,6-dioxo-4-(trifluoromethyl)-1(2H)-pyrimidinyl]-1,2-benzisothiazol-3-yl}oxy}acetonitrile
反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][N:8]=[C:7]([O:10][CH2:11][C:12]#[N:13])[C:6]=2[CH:14]=1.CN(C)[C:17]1[O:18][C:19](=[O:27])[CH:20]=[C:21]([C:23]([F:26])([F:25])[F:24])[N:22]=1>C(O)(=O)C>[O:18]=[C:17]1[NH:22][C:21]([C:23]([F:24])([F:25])[F:26])=[CH:20][C:19](=[O:27])[N:1]1[C:2]1[CH:3]=[CH:4][C:5]2[S:9][N:8]=[C:7]([O:10][CH2:11][C:12]#[N:13])[C:6]=2[CH:14]=1参加物
4
実験手順
A mixture of [(5-amino-1,2-benzisothiazol-3-yl)oxy]acetonitrile (4.30 g, 21.0 mmol) and 2-dimethylamino-4-(trifluoromethyl)-6H-1,3-oxazin-6-one (4.37 g, 21.0 mmol) in acetic acid is refluxed for three hours, stirred overnight at room temperature, and poured into an ice-water mixture. The resultant aqueous mixture is filtered to obtain a solid. The solid is washed with water and dried overnight in a vacuum oven at 55° C. to give the title product as a brown solid (2.63 g, mp 254-258° C.).