2-Chloro-10H-pyridazino(6,1-b)quinazolin-10-one → HCID 20284571、化合物
反応式
Cl[C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2.[CH3:17][O-:18].[Na+]>CO>[CH3:17][O:18][C:2]1[CH:3]=[CH:4][C:5]2[N:14]([N:15]=1)[C:13](=[O:16])[C:12]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[N:6]=2参加物
4
実験手順
2-Chloro-10H-pyridazino[3,2-b]quinazolin-10-one (2.3 g) and sodium methoxide (1.1 g) in 100 ml of methanol was heated at 60° C. for 5 hours. After completion of the reaction, the solvent was removed by distillation, followed by addition of an aqueous solution of acetic acid. The precipitates were collected by filtration and recrystallized from methanol to give 1.6 g of 2-methoxy-10H-pyridazino[3,2-b]-quinazolin-10-one (Compound No. 1). M.P., 222.5°-223.0° C.
後処理
- customAfter completion of the reaction
- customthe solvent was removed by distillation
- additionfollowed by addition of an aqueous solution of acetic acid
- filtrationThe precipitates were collected by filtration
- customrecrystallized from methanol
出典と根拠
- ORDレコード
- ord-f2a92ad9e11149c287c2f3e9fce12779
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04256483
反応ノート
読み込み中…