4-Amino-1-butanol → HCID 178526250、化合物

HRID 1274976ノート

反応式

HRID 1274976 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][OH:6].Cl.Cl[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-:15].C([O-])(O)=O.[Na+]>C(O)(CC)(C)C.CCO>[OH:6][CH2:5][CH2:4][CH2:3][CH2:2][NH:1][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][N+:10]=1[O-:15]

参加物

6

反応物 3

HCID 258684-Amino-1-butanolHCID 88478Chloride 2-chloropyridinium 1-oxideHCID 516892Sodium Bicarbonate

生成物 1

HCID 178526250HCID 178526250、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 64052-Methyl-2-butanol溶媒

実験手順

A mixture of 4-amino-1-butanol (1.76 g, 20 mmol), 2-chloropyridine N-oxide hydrochloride (3.98 g, 24 mmol), and NaHCO3 (8.40 g, 100 mmol) in tert-amyl alcohol (50 mL) is heated at reflux under argon. After 48 h, the reaction is cooled, diluted with EtOH, filtered, and concentrated. The residue is reconcentrated from toluene, and chromatographed (silica gel) to give the title compound.

後処理

  1. temperatureis heated
  2. temperatureat reflux under argon
  3. temperaturethe reaction is cooled
  4. filtrationfiltered
  5. concentrationconcentrated
  6. customchromatographed (silica gel)

出典と根拠

ORDレコード
ord-3b6c24c0bc6444779df62ea104da4529
出典データセット
uspto-grants-2000_12
特許番号
US06159964

反応ノート

読み込み中…