1-Naphthoic acid → 5-Bromonaphthalene-1-carboxylic acid

HRID 1275002

反応式

HRID 1275002 の反応式
[C:1]1([C:11]([OH:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[Br:14]Br>C(O)(=O)C>[Br:14][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]2[C:5]=1[CH:4]=[CH:3][CH:2]=[C:1]2[C:11]([OH:13])=[O:12]

参加物

4

反応物 2

HCID 68471-Naphthoic acidHCID 24408Bromine

生成物 1

HCID 6976055-Bromonaphthalene-1-carboxylic acid収率 76.6%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

実験手順

To a stirred suspension of 1-naphthoic acid (90 g, 0.52 mol) in glacial acetic acid at 100° C. was added bromine (84 g, 0.52 mol). The reaction was stirred at this temperature for 1.5 hours and then allowed to cool overnight. The resulting slurry was diluted with glacial acetic acid, the solid collected by filtration, resuspended in water, filtered and dried in vacuo to give 5-bromo-1-napthoic acid (100 g). The acid was converted to the title compound using a similar procedure to Description 3 (68%).

後処理

  1. temperatureto cool overnight
  2. filtrationthe solid collected by filtration
  3. filtrationfiltered
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-e9e92af35b7048118ae5132f21b707db
出典データセット
uspto-grants-2000_12
特許番号
US06159979

関連ノート

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