Hydrochloric Acid → 3-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethoxymethyleneamino-4-trifluoromethylthiopyrazole

HRID 1275106

反応式

HRID 1275106 の反応式
[NH2:1][C:2]1[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:17])([F:16])[F:15])=[CH:9][C:8]=2[Cl:18])[N:5]=[C:4]([C:19]#[N:20])[C:3]=1[S:21][C:22]([F:25])([F:24])[F:23].Cl.[CH:27](OCC)(OCC)[O:28][CH2:29][CH3:30]>>[C:19]([C:4]1[C:3]([S:21][C:22]([F:25])([F:24])[F:23])=[C:2]([N:1]=[CH:27][O:28][CH2:29][CH3:30])[N:6]([C:7]2[C:12]([Cl:13])=[CH:11][C:10]([C:14]([F:15])([F:16])[F:17])=[CH:9][C:8]=2[Cl:18])[N:5]=1)#[N:20]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 31214Ethyl orthoformateHCID 9953940Fipronil sulfide

生成物 1

HCID 540930933-Cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethoxymethyleneamino-4-trifluoromethylthiopyrazole

反応条件

温度
50 °C

実験手順

A solution of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole (500 g) in triethyl orthoformate was treated with concentrated hydrochloric acid (10 ml) and heated at 50° C. After 8 hours the reaction mixture was evaporated to give a solid which was washed (heptane) and air-dried to give 3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethoxymethylideneamino-4-trifluoromethylthiopyrazole (217 g), m.p. 68° C.

後処理

  1. customAfter 8 hours the reaction mixture was evaporated
  2. customto give a solid which
  3. washwas washed (heptane)
  4. customair-dried

出典と根拠

ORDレコード
ord-121614e0982b42baa82a075c6ec0208f
出典データセット
uspto-grants-2000_12
特許番号
US06160002

関連ノート

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