Hydrochloric Acid → (R)-4-chloro-1-(3,5-dimethylphenyl)-3-methylbutan-1-one

HRID 1275185

反応式

HRID 1275185 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([CH3:17])[CH:16]=1)[C:5]([C@H:7]1[CH:11]([CH3:12])[CH2:10]OC1=O)=[O:6].[ClH:18].C(=O)(O)[O-].[Na+]>>[Cl:18][CH2:10][C@H:11]([CH3:12])[CH2:7][C:5]([C:4]1[CH:3]=[C:2]([CH3:1])[CH:16]=[C:15]([CH3:17])[CH:14]=1)=[O:6]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 516892Sodium Bicarbonate2 回HCID 53860757(R)-3-(3,5-dimethylbenzoyl)-4-methyldihydrofuran-2-one

生成物 1

HCID 53672991(R)-4-chloro-1-(3,5-dimethylphenyl)-3-methylbutan-1-one

実験手順

To a solution of (R)-3-(3,5-dimethylbenzoyl)-4-methyldihydrofuran-2-one (2.42 g in 15 mL dioxane) was added 15 mL conc. hydrochloric acid and the mixture heated to reflux on an oil bath. After one hour, the reaction was poured into cold, saturated aqueous sodium bicarbonate. Additional solid sodium bicarbonate was added until all acid was neutralized. This was then extracted with ethyl acetate, washed with brine. Concentration in vacuo provided the title compound (2.12 g).

後処理

  1. temperaturethe mixture heated
  2. temperatureto reflux on an oil bath
  3. extractionThis was then extracted with ethyl acetate
  4. washwashed with brine
  5. concentrationConcentration in vacuo

出典と根拠

ORDレコード
ord-416ee6ec866d44078a574ba1abe4bd43
出典データセット
uspto-grants-2000_12
特許番号
US06159989

関連ノート

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