Sodium hydrosulfide hydrate → Sodium 2-hydroxy-3-sulfanylpropane-1-sulfonate
反応式
O.Cl[CH2:3][CH:4]([OH:10])[CH2:5][S:6]([O-:9])(=[O:8])=[O:7].[Na+:11].O.[SH-:13].[Na+]>CN(C=O)C>[SH:13][CH2:3][CH:4]([OH:10])[CH2:5][S:6]([O-:9])(=[O:8])=[O:7].[Na+:11]参加物
4
実験手順
To sodium 3-chloro-2-hydroxypropanesulfonate hydrate (2.0 g), sodium hydrosulfide hydrate (0.42 g) was added in 10 mL DMF. The mixture was refluxed overnight. When the reaction mixture was cooled down, white solid was isolated, rinsed with ether and acetone to obtain 1.9 g crude sodium 3-mercapto-2-hydroxypropane sulfonate. The crude product was dissolved in water and preferentially precipitated the desired product by adding acetone. The precipitated product was then filtered and dried under vacuum to get 1.04 g of the title compound.
後処理
- temperatureThe mixture was refluxed overnight
- temperatureWhen the reaction mixture was cooled down
- customwhite solid was isolated
- washrinsed with ether and acetone
出典と根拠
- ORDレコード
- ord-dba88060dfeb4f4c8d98aa631c8a672c
- 出典データセット
- uspto-grants-2000_12
- 特許番号
- US06160167
反応ノート
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