Bromine → HCID 22118464、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:7]([CH3:18])=[C:8]2[C:13](=[C:14]([CH3:16])[CH:15]=1)[S:12][CH2:11][CH2:10][C:9]2=[O:17])=[O:5])[CH3:2].[Br:19]Br>C(O)C>[Br:19][CH:10]1[C:9](=[O:17])[C:8]2[C:13](=[C:14]([CH3:16])[CH:15]=[C:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[C:7]=2[CH3:18])[S:12][CH2:11]1参加物
4
実験手順
1.9 Grams (7.2 mmol) of 6-ethoxycarbonyl-5,8-dimethylthiochroman-4-one was dissolved in 28 ml of ethanol. Then, 1.2 g (7.5 mmol) of bromine was dropwise added with an ice bath cooling, and the mixture was stirred at the same temperature for 1 hour, then the ice bath was removed and further stirred for 1 hour. Water was added to the reaction mixture, and the reaction mixture was extracted with chloroform three times. An organic layer was washed with a saturated sodium chloride aqueous solution three times, and dried over anhydrous sodium sulfate. The solvent was distilled off under reduced pressure to give 2.4 g (yield 97%) of the titled compound.