(3,4-Dichloropyridin-2-yl)methanol → 2-[(3-Chloro-2-hydroxymethyl-pyridin-4-yl)-methylamino]-ethanol

HRID 1275573ノート

反応式

HRID 1275573 の反応式
[Cl:1][C:2]1[C:3]([CH2:9][OH:10])=[N:4][CH:5]=[CH:6][C:7]=1Cl>CNCCO>[Cl:1][C:2]1[C:3]([CH2:9][OH:10])=[N:4][CH:5]=[CH:6][C:7]=1[N:4]([CH2:3][CH2:9][OH:10])[CH3:5]

参加物

3

反応物 1

HCID 22117301(3,4-Dichloropyridin-2-yl)methanol

生成物 1

HCID 537528042-[(3-Chloro-2-hydroxymethyl-pyridin-4-yl)-methylamino]-ethanol

試薬・触媒・溶媒 1

HCID 80162-(Methylamino)ethanol溶媒

実験手順

A mixture of 3,4-dichloro-2-hydroxymethylpyridine (J. Med. Chem. 1989, 32, 1970) (2.5 g) in 2-methylaminoethanol (30 ml) is heated at 160° C. for 2.5 h in a steel autoclave, the excess amine is stripped off in a high vacuum and the residue which remains is chromatographed on silica gel (dichloromethane/methanol 95/5). Yield: 2.3 g as a yellowish oil.

後処理

  1. customthe residue which remains is chromatographed on silica gel (dichloromethane/methanol 95/5)

出典と根拠

ORDレコード
ord-a6007fa1b5ea4fa3af1401b98d179152
出典データセット
uspto-grants-2000_12
特許番号
US06162809

反応ノート

読み込み中…