Toluene → 7-Methyl-6-(2-imidazolinylamino)indole
反応式
[N:1]([C:4]1[C:12]([CH3:13])=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)=C=S.[CH2:14]([NH2:17])[CH2:15][NH2:16].[C:18]1(C)C=CC=CC=1>>[CH3:13][C:12]1[C:4]([NH:1][N:16]2[CH2:15][CH2:14][N:17]=[CH:18]2)=[CH:5][CH:6]=[C:7]2[C:11]=1[NH:10][CH:9]=[CH:8]2参加物
4
実験手順
A solution of 6-isothiocyanato-7-methylindole (0.85 g, 4.52 mmol) in 25 mL of toluene is added to a solution of ethylenediamine (1.06 mL, 15.8 mmol) in 50 mL of toluene. The milky white mixture is stirred for 30 minutes as the desired product precipitates. The reaction is filtered to yield 1.1 g of 6-[-N'-(2-aminoethyl)thioureido]-7-methylindole as a flaky white solid (99% yield).
出典と根拠
- ORDレコード
- ord-3a97ea4877b54c01b86c028b4180851e
- 出典データセット
- uspto-grants-2000_12
- 特許番号
- US06162818
反応ノート
読み込み中…