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Aniline → Prinomide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Aniline | HCID 6115 | — |
| 反応物 | 1-Methyl-beta-oxo-alpha-ethoxycarbonyl-2-pyrrolepropionitrile | HCID 20285413 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | Prinomide | HCID 60352 | — |
反応手順
The mixture of 1.1 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 1.1 g of aniline and 60 ml of xylene, is refluxed for 41/2 hours. After standing and cooling to room temperature overnight, the solution is filtered, evaporated and the residue recrystallized from methanol, to yield the 1-methyl-β-oxo-α-phenylcarbamoyl-2-pyrrolpropionitrile melting at 173°-174°; it is identical with that obtained according to Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04256759 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-92b9856cc49644c097908df62f3abed0 |
| 出典メモ | uspto-grants-1981_03 |