Acetamide, 2-cyano-N-phenyl- → Prinomide

HRID 127589

反応式

HRID 127589 の反応式
[C:1]1([NH:7][C:8]([CH2:10][C:11]#[N:12])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.CC(C)([O-])C.[K+].[CH3:19][N:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25](Cl)=[O:26]>CN(C)C=O>[CH3:19][N:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:25](=[O:26])[CH:10]([C:8](=[O:9])[NH:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:11]#[N:12]

参加物

5

反応物 3

HCID 69296Acetamide, 2-cyano-N-phenyl-HCID 27950921-Methyl-1H-pyrrole-2-carbonyl chlorideHCID 23665647Potassium tert-butoxide

生成物 1

HCID 60352Prinomide

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To the solution of 4.0 g of phenylcarbamoyl-acetonitrile in 50 ml of dimethylformamide 28 g of potassium tert. butoxide are added while stirring under nitrogen. After 2 hours the resulting suspension is cooled to 5° and 4.0 g of 1-methylpyrrol-2-carboxylic acid chloride (U.S. Pat. No. 3,551,571) are added during 10 minutes. The mixture is stirred for 18 hours at room temperature, poured into 300 ml of ice water and the precipitate formed filtered off. It is washed with water, dried and recrystallized from ethanol, to yield the 1-methyl-β-oxo-α-phenylcarbamoyl-2-pyrrolpropionitrile melting at 172°-174°; it is identical with that obtained according to Example 1.

後処理

  1. temperatureAfter 2 hours the resulting suspension is cooled to 5°
  2. addition3,551,571) are added during 10 minutes
  3. stirringThe mixture is stirred for 18 hours at room temperature
  4. customthe precipitate formed
  5. filtrationfiltered off
  6. washIt is washed with water
  7. customdried
  8. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-b1750a43d37a4d2da5eb70559411b709
出典データセット
uspto-grants-1981_03
特許番号
US04256759

関連ノート

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