2-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazole → 4,5-Dihydro-4,4-dimethyl-2-[4-methyl-2-[2-[2,3-dimethylphenyl]ethyl]phenyl]oxazole

関与物質

反応手順

n-Butyllithium (6.9 ml of a 2.5M soln in hexanes) was added dropwise to the product of example 21 step (i) (3.51 g) in tetrahydrofuran (60 ml) at -78° C. After 2 hours the product from step (i) (3.45 g) was added. After 1 hour the solution was left to warm to room temperature. The solution was quenched with water and extracted with ethyl acetate. The organic solution was dried (MgSO4) and evaporated under reduced pressure. Yield 1.83 g.

情報源と証拠