2-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazole → 4,5-Dihydro-4,4-dimethyl-2-[4-methyl-2-[2-[2,3-dimethylphenyl]ethyl]phenyl]oxazole

HRID 1275905

反応式

HRID 1275905 の反応式
[CH2:1]([Li])[CH2:2][CH2:3][CH3:4].[CH3:6][C:7]1([CH3:20])[CH2:11][O:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH3:19])=[N:8]1>O1CCCC1>[CH3:6][C:7]1([CH3:20])[CH2:11][O:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][C:13]=2[CH2:19][CH2:1][C:2]2[CH:14]=[CH:13][CH:12]=[C:17]([CH3:16])[C:3]=2[CH3:4])=[N:8]1

参加物

4

反応物 2

HCID 221172732-[2,4-Dimethylphenyl]-4,5-dihydro-4,4-dimethyloxazoleHCID 178418339Butyllithium

生成物 1

HCID 221172044,5-Dihydro-4,4-dimethyl-2-[4-methyl-2-[2-[2,3-dimethylphenyl]ethyl]phenyl]oxazole

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

n-Butyllithium (6.9 ml of a 2.5M soln in hexanes) was added dropwise to the product of example 21 step (i) (3.51 g) in tetrahydrofuran (60 ml) at -78° C. After 2 hours the product from step (i) (3.45 g) was added. After 1 hour the solution was left to warm to room temperature. The solution was quenched with water and extracted with ethyl acetate. The organic solution was dried (MgSO4) and evaporated under reduced pressure. Yield 1.83 g.

後処理

  1. customThe solution was quenched with water
  2. extractionextracted with ethyl acetate
  3. dry with materialThe organic solution was dried (MgSO4)
  4. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-91762cdd6cfb4b918869ccc2090b8faa
出典データセット
uspto-grants-2000_12
特許番号
US06162808

関連ノート

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