5-Bromomethyl-2-furancarboxylic acid ethyl ester → (+/-)-5-[[5-{2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

HRID 1275913

反応式

HRID 1275913 の反応式
[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[NH:21][CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2].[CH2:27]([O:29][C:30]([C:32]1[O:33][C:34]([CH2:37]Br)=[CH:35][CH:36]=1)=[O:31])[CH3:28]>>[CH2:1]([C:3]1[CH:26]=[CH:25][C:6]2[CH:7]([C:17]3[C:18](=[O:24])[NH:19][C:20](=[O:23])[N:21]([CH2:37][C:34]4[O:33][C:32]([C:30]([O:29][CH2:27][CH3:28])=[O:31])=[CH:36][CH:35]=4)[CH:22]=3)[C:8]3[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][C:9]=3[CH:10]=[CH:11][C:5]=2[CH:4]=1)[CH3:2]

参加物

3

反応物 2

HCID 137895295-Bromomethyl-2-furancarboxylic acid ethyl esterHCID 22117281(+/-)-5-[2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl]-2,4(1H,3H)-pyrimidinedione

生成物 1

HCID 131722232(+/-)-5-[[5-{2-Ethyl-8-methyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-2-furancarboxylic acid, ethyl ester

実験手順

The subtitle compound was prepared from the product of step (vi) (0.6 g) and 5-bromomethyl-2-furancarboxylic acid ethyl ester (J. Chem. Soc. Perkin Trans. 1, 1981, 1125, Bull. Chem. Soc. Jpn. 1987, 60, 1807)(0.47 g) according to the method of example 1 step (iv). Purification was by chromatography eluting with 50% ethyl acetate in isohexane. Yield 0.19 g.

後処理

  1. customPurification
  2. washeluting with 50% ethyl acetate in isohexane

出典と根拠

ORDレコード
ord-2210aba61e994dd9ba8128c2a380af2b
出典データセット
uspto-grants-2000_12
特許番号
US06162808

関連ノート

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