3-Bromobenzyl bromide → 2-[2-[2-[3-Bromophenyl]ethyl]phenyl]-4,5-dihydro-4,4-dimethyloxazole

HRID 1275914ノート

反応式

HRID 1275914 の反応式
[CH3:1][C:2]1([CH3:14])[CH2:6][O:5][C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[CH3:13])=[N:3]1.[Br:15][C:16]1[CH:17]=[C:18]([CH:21]=[CH:22][CH:23]=1)[CH2:19]Br>>[Br:15][C:16]1[CH:17]=[C:18]([CH2:19][CH2:13][C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C:4]2[O:5][CH2:6][C:2]([CH3:14])([CH3:1])[N:3]=2)[CH:21]=[CH:22][CH:23]=1

参加物

3

反応物 2

HCID 699793-Bromobenzyl bromideHCID 104878894,4-Dimethyl-2-(2-methylphenyl)-4,5-dihydro-1,3-oxazole

生成物 1

HCID 221172632-[2-[2-[3-Bromophenyl]ethyl]phenyl]-4,5-dihydro-4,4-dimethyloxazole

実験手順

The subtitle compound was prepared from the product of step (i) (1 g) and 3-bromobenzylbromide (1.32 g) according to the method of example 21 step (ii). Purification was by chromatography eluting with 5-10% ethyl acetate inisohexane. Yield 0.64 g.

後処理

  1. customPurification
  2. washeluting with 5-10% ethyl acetate inisohexane

出典と根拠

ORDレコード
ord-6ba459a5da5d465f8b78a963cdf4d369
出典データセット
uspto-grants-2000_12
特許番号
US06162808

反応ノート

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