Acetone → HCID 21707621、化合物

HRID 1275950ノート

反応式

HRID 1275950 の反応式
[CH3:1][C:2]12[CH2:7][CH:6]1[CH2:5][CH:4]([CH2:8][CH:9]1OCC[O:10]1)[C:3]2([CH3:15])[CH3:14].CC(C)=O.Cl>O>[CH3:1][C:2]12[CH2:7][CH:6]1[CH2:5][CH:4]([CH2:8][CH:9]=[O:10])[C:3]2([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 180AcetoneHCID 313Hydrochloric AcidHCID 21707623HCID 21707623、化合物

生成物 1

HCID 21707621HCID 21707621、化合物収率 79%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 11.0 g (52 mmol) of 2-(1,2,2-trimethylbicyclo[3.1.0]hex-3-ylmethyl)-[1,3]-dioxolane, 80 ml of acetone, 40 ml of water, 1.5 ml of conc. hydrochloric acid and 10 g of silica gel was stirred at reflux for 4 hours. After filtration, the solution was diluted with diethyl ether, washed with water, dried (MgSO4) and evaporated in vacuo. Kugelrohr distillation of the residue gave 6.8 g (79% yield) of (1,2,2-trimethylbicyclo[3.1.0]hex-3-yl)ethanal.

後処理

  1. temperatureat reflux for 4 hours
  2. filtrationAfter filtration
  3. additionthe solution was diluted with diethyl ether
  4. washwashed with water
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo
  7. distillationKugelrohr distillation of the residue

出典と根拠

ORDレコード
ord-99cae8c6ddb2499dbd31f10da6c87b0e
出典データセット
uspto-grants-2000_12
特許番号
US06162954

反応ノート

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