Water → [3-(Butylamino)phenyl]methanol

HRID 1275997

反応式

HRID 1275997 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][OH:6].C([O-])(O)=O.[Na+].Br[CH2:16][CH2:17][CH2:18][CH3:19].O>CS(C)=O>[CH2:16]([NH:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([CH2:5][OH:6])[CH:3]=1)[CH2:17][CH2:18][CH3:19]

参加物

6

反応物 4

HCID 962WaterHCID 8002Butyl bromideHCID 802933-Aminobenzyl alcoholHCID 516892Sodium Bicarbonate

生成物 1

HCID 22322603[3-(Butylamino)phenyl]methanol

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

反応条件

温度
50 °C

実験手順

To a solution of 3.69 g (30 mmol) of 3-amino benzyl alcohol in 20 ml DMSO was added 3.78 g (45 mmol) solid NaHCO3 and 2.91 ml (27 mmol) 1-bromobutane. The reaction was allowed to stir at 50° C. for 18 hours (overnight). Reaction was worked up by adding 250 ml water and product was extracted in ethyl acetate. Water was added, and the resultant mixture was extracted with EtOAc. The organic layer was washed with water and brine.

後処理

  1. customReaction
  2. extractionwas extracted in ethyl acetate
  3. additionWater was added
  4. extractionthe resultant mixture was extracted with EtOAc
  5. washThe organic layer was washed with water and brine

出典と根拠

ORDレコード
ord-8aa5b48108b44a218f38627f39433221
出典データセット
uspto-grants-2000_12
特許番号
US06162927

関連ノート

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