Dichloromethane → H-Phe-Met-OMe.HCl

HRID 127604ノート

反応式

HRID 127604 の反応式
[NH:1](C(OC(C)(C)C)=O)[C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20][CH3:21])=[O:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(Cl)[Cl:30]>Cl>[NH2:1][C@H:2]([C:10]([NH:12][C@H:13]([C:18]([O:20][CH3:21])=[O:19])[CH2:14][CH2:15][S:16][CH3:17])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[ClH:30]

参加物

4

反応物 2

HCID 6344DichloromethaneHCID 8022451tert-Butoxycarbonyl-phenylalanyl-methionine methyl ester

生成物 1

HCID 67685067H-Phe-Met-OMe.HCl

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

11.83 g of Boc-Phe-Met-OMe (see Biochemistry, 8, 4183 (1969), incorporated herein) is dissolved in 100 ml methylene chloride after which HCl is passed into the solution for about 40 minutes. After evaporation of the solution to dryness, 75 ml ethyl acetate is added, resulting in a precipitate. The solid substance is separated by filtration, washed with petroleum ether, and dried. Melting point 123°-124° C. Rf in To:EtOH (8:2)=0.43 on SiO2.

後処理

  1. customAfter evaporation of the solution to dryness, 75 ml ethyl acetate
  2. additionis added
  3. customresulting in a precipitate
  4. customThe solid substance is separated by filtration
  5. washwashed with petroleum ether
  6. customdried

出典と根拠

ORDレコード
ord-6c4d992ebbd846aa81b24e6a96ca344f
出典データセット
uspto-grants-1981_03
特許番号
US04256736

反応ノート

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