Thiophene → 5-Chloro-1-(2-thienyl)-1-pentanone

反応式

[Cl-].[Al+3].[Cl-].[Cl-].[S:5]1[CH:9]=[CH:8][CH:7]=[CH:6]1.[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15](Cl)=[O:16]>>[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([C:6]1[S:5][CH:9]=[CH:8][CH:7]=1)=[O:16]

参加物

反応物 3

HCID 8030Thiophene

HCID 740895-Chlorovaleryl chloride

HCID 6451240Aluminum(III) Chloride

生成物 1

HCID 49129955-Chloro-1-(2-thienyl)-1-pentanone

実験手順

16 g (0.120 mol) of aluminium chloride are introduced portionwise over 15 min into a solution, maintained at about +5°, of 20.2 g (0.240 mol) of thiophene and 15.5 g (0.100 mol) of 5-chlorovaleryl chloride and the mixture is stirred for 5 h at room temperature. After removal of the supernatant by means of separating the phases by settling, the reaction medium is taken up in 120 ml of 3N hydrochloric acid solution and extracted with chloroform.