Water → Methyl 4[2-methyl-6-(2-oxopyrrolidin-1-yl)pyridin-3-yl]benzoate

HRID 1276291ノート

反応式

HRID 1276291 の反応式
Cl[CH2:2][CH2:3][CH2:4][C:5]([NH:7][C:8]1[N:13]=[C:12]([CH3:14])[C:11]([C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)=[CH:10][CH:9]=1)=[O:6].CC(C)([O-])C.[K+].O>CN(C=O)C>[CH3:14][C:12]1[C:11]([C:15]2[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=2)=[CH:10][CH:9]=[C:8]([N:7]2[CH2:2][CH2:3][CH2:4][C:5]2=[O:6])[N:13]=1

参加物

5

反応物 3

HCID 962WaterHCID 22115876HCID 22115876、化合物HCID 23665647Potassium tert-butoxide

生成物 1

HCID 22115894Methyl 4[2-methyl-6-(2-oxopyrrolidin-1-yl)pyridin-3-yl]benzoate収率 85.3%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A stirred solution of methyl 4[6-(4-chlorobutanoylamino)-2-methylpyridin-3-yl]benzoate (D8, 0.60 g, 1.7 mmole) in DMF (7 ml) at 25° C. under argon was treated portionwise over 15 minutes with potassium t-butoxide (0.23 g, 2.0 mmole). The mixture was stirred for 3 h, then poured into water (100 ml) and extracted with ethyl acetate. The extract was washed with water, dried (Na2SO4) and concentrated in vacuo to afford the title compound as an orange solid (0.45 g, 85%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with water
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-13c0d5e0568a4d0b817845cbcc5478be
出典データセット
uspto-grants-2000_12
特許番号
US06166034

反応ノート

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