Hydrochloric Acid → 2-(3-Bromophenyl)propan-2-ol

HRID 1276532ノート

反応式

HRID 1276532 の反応式
[CH3:1][Mg]Br.[CH3:4][C:5]([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([Br:13])[CH:8]=1)=[O:6].O.Cl>C(OCC)C>[Br:13][C:9]1[CH:8]=[C:7]([C:5]([OH:6])([CH3:1])[CH3:4])[CH:12]=[CH:11][CH:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 165023'-BromoacetophenoneHCID 178418573HCID 178418573、化合物

生成物 1

HCID 150723832-(3-Bromophenyl)propan-2-ol

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

To a stirred solution of methylmagnesium bromide (60 mL of a 3.0 M solution in diethyl ether) at 0° C. was added dropwise a solution of 3-bromoacetophenone (29.8 grams) in 75 mL of diethyl ether. Once the addition was complete, the mixture was stirred for 0.5 hours and poured into water. The aqueous phase was acidified with 1M hydrochloric acid and extracted with three portions of diethyl ether. The combined ether layers were washed with saturated sodium bicarbonate, concentrated to afford 30.4 grams of the title compound. 1H NMR δ7.72 (br s, 1), 7.49 (d, 1, J=7.8), 7.37 (d, 1, J=7.9), 7.25 (dd, 1, J=7.8, 7.9), 4.19 (s, 1), 1.50 (br s, 6).

後処理

  1. additionOnce the addition
  2. extractionextracted with three portions of diethyl ether
  3. washThe combined ether layers were washed with saturated sodium bicarbonate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-0df5965ff49c4ffdb52213cbd0310d10
出典データセット
uspto-grants-2000_12
特許番号
US06166064

反応ノート

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