L-Phenylalanine, methyl ester → L-Phenylalanine, methyl ester

HRID 127662

反応式

HRID 127662 の反応式
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:17]([OH:19])=O)[CH2:13][C:14]([OH:16])=[O:15])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:20][O:21][C:22](=[O:32])[C@H:23]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH2:24]>>[CH3:20][O:21][C:22](=[O:32])[C@H:23]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH:24][C:17](=[O:19])[C@H:12]([CH2:13][C:14](=[O:15])[OH:16])[NH:11][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:10].[CH3:20][O:21][C:22](=[O:32])[C@H:23]([CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[NH2:24]

参加物

4

反応物 2

HCID 736234L-Phenylalanine, methyl esterHCID 2723942N-(Benzyloxycarbonyl)aspartic acid

生成物 2

HCID 736234L-Phenylalanine, methyl ester収率 95.5%HCID 10159630N-(Benzyloxycarbonyl)-L-aspartyl-L-phenylalanine methyl ester

反応条件

温度
38 °C

実験手順

A 267.2 mg (1 m mol) of N-benzyloxycarbonyl-L-aspartic acid and 537.6 mg (3 m mol) of L-phenylalanine methyl ester were dissolved in 5 ml of McIlvain's buffer solution (pH:7.0). The resulting solution was admixed with 100 mg of Thermoase and 100 mg of potato inhibitor and shaken at 38° C. for 20 hours. The precipitate was collected and washed with water and dried to obtain 580 mg of a crude crystalline addition compound of N-benzyloxycarbonyl-L-aspartyl-L-phenylalanine methyl ester and L-phenylalanine methyl ester (1:1) (melting point: 123° to 125° C.; Yield: 95.5% based on N-benzyloxycarbonyl-L-aspartic acid).

後処理

  1. customThe precipitate was collected
  2. washwashed with water
  3. customdried

出典と根拠

ORDレコード
ord-b3787531371f49e5a90121dfcb20b18e
出典データセット
uspto-grants-1981_03
特許番号
US04256836

関連ノート

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