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Cyclopropylamine → HCID 178418304、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Cyclopropylamine | HCID 69828 | — |
| 反応物 | Ethyl 2-(2,4,5-trifluoro-6-methylbenzoyl)-3-ethoxyacrylate | HCID 54242925 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178418304 | HCID 178418304 | — |
反応手順
Ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-ethoxyacrylate (3.5 g) is dissolved in ethanol (25 ml) and thereto cyclopropylamine (0.84 ml) is added dropwise under ice-cooling. After stirring at room temperature for 30 minutes, the mixture is concentrated and the residue is purified with column chromatography (silica-gel, dichloromethane: n-hexane =1: 1) to give ethyl 2-(2-methyl-3,4,6-trifluorobenzoyl)-3-cyclopropylaminoacrylate (2.7 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05723648 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-a6bc9092d4d54296b6f4a8701204549f |
| 出典メモ | uspto-grants-1998_03 |