1-(4-Nitrobenzyl)pyrrolidine → 4-(Pyrrolidin-1-ylmethyl)aniline

HRID 1277018

反応式

HRID 1277018 の反応式
[N+:1]([C:4]1[CH:15]=[CH:14][C:7]([CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:15]=[CH:14][C:7]([CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[CH:6][CH:5]=1

参加物

3

反応物 1

HCID 7835221-(4-Nitrobenzyl)pyrrolidine

生成物 1

HCID 7768524-(Pyrrolidin-1-ylmethyl)aniline収率 42.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (100 ml) was dissolved 1-(4-nitrobenzyl)-pyrrolidine (23.5 g), and to the mixture was added dried 10% palladium on carbon (1.00 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 20 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate/triethylamine=10/1) to give 1-(4-aminobenzyl)pyrrolidine (8.54 g) as orange oil.

後処理

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (1.00 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was separated
  6. custompurified with column chromatography (ethyl acetate/triethylamine=10/1)

出典と根拠

ORDレコード
ord-0ecdbbb4347949079b6be9802c9695f8
出典データセット
uspto-grants-2000_12
特許番号
US06166006

関連ノート

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