tert-Butyldimethyl((4-nitrobenzyl)oxy)silane → 4-Aminobenzyloxy-tert-butyldimethylsilane

HRID 1277033ノート

反応式

HRID 1277033 の反応式
[C:1]([Si:5]([CH3:18])([CH3:17])[O:6][CH2:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>C(O)C>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([CH2:7][O:6][Si:5]([C:1]([CH3:2])([CH3:3])[CH3:4])([CH3:17])[CH3:18])=[CH:9][CH:10]=1

参加物

3

反応物 1

HCID 11065418tert-Butyldimethyl((4-nitrobenzyl)oxy)silane

生成物 1

HCID 110754704-Aminobenzyloxy-tert-butyldimethylsilane収率 94.2%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (80 ml) was dissolved tert-butyldimethyl-4-nitrobenzyloxysilane (16.5 g), and to the mixture was added dried 5% palladium on carbon (0.83 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 7.5hours. The palladium was filtered off, and the filtrate was concentrated. The residue was separated and purified with column chromatography (ethyl acetate/hexane=1/4) to give 4-aminobenzyloxy-tert-butyldimethylsilane (13.8 g) as colorless oil.

後処理

  1. additionto the mixture was added
  2. dry with materialdried 5% palladium on carbon (0.83 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was separated
  6. custompurified with column chromatography (ethyl acetate/hexane=1/4)

出典と根拠

ORDレコード
ord-d2b93e05d82747b2a58f3fc821d6adb4
出典データセット
uspto-grants-2000_12
特許番号
US06166006

反応ノート

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