2-Pyridinemethanol,a-(4-nitrophenyl)- → (4-Aminophenyl) (2-pyridyl)methanol

HRID 1277041ノート

反応式

HRID 1277041 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1)([O-])=O>C(O)C>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][N:13]=2)[OH:11])=[CH:6][CH:5]=1

参加物

3

反応物 1

HCID 103537882-Pyridinemethanol,a-(4-nitrophenyl)-

生成物 1

HCID 10420323(4-Aminophenyl) (2-pyridyl)methanol収率 95%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

In ethanol (50 ml) was dissolved (4-nitrophenyl)-(2-pyridyl)methanol (2.30 g), and to the mixture was added dried 10% palladium on carbon (0.12 g). Under hydrogen atmosphere, the mixture was stirred at room temperature under atmospheric pressure for 19 hours. The palladium was filtered off, and the filtrate was concentrated. The residue was recrystallized f rom ethyl acetate-hexane to give (4-aminophenyl) (2-pyridyl)methanol (1.90 g) as pale yellow crystals.

後処理

  1. additionto the mixture was added
  2. dry with materialdried 10% palladium on carbon (0.12 g)
  3. filtrationThe palladium was filtered off
  4. concentrationthe filtrate was concentrated
  5. customThe residue was recrystallized f

出典と根拠

ORDレコード
ord-5a105c65953a483a8e1cb6b855e118ad
出典データセット
uspto-grants-2000_12
特許番号
US06166006

反応ノート

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