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Triethylamine → 3-Isoxazolamine, 5-(1,1-dimethylethyl)-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Pentanenitrile, 4,4-dimethyl-3-oxo- | HCID 108871 | — |
| 反応物 | Hydroxylamine, sulfate (1:1) | HCID 159255 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 3-Isoxazolamine, 5-(1,1-dimethylethyl)- | HCID 171473 | 81.7% |
反応手順
A suspension of pivaloylacetonitrile (12.52 g) and triethylamine (11.27 g) in water (200 ml) is stirred and mixed with hydroxylamine sulfate (9.03 g). pH 8.22. The reaction mixture is treated as in Example 2 to give 3-amino-5-t-butylisoxazole (11.45 g; yield, 81.7%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04256899 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-d73c023895844ceaa0b5ec960b928bde |
| 出典メモ | uspto-grants-1981_03 |