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5-Aminopentan-1-ol → 2-(5-Hydroxypentyl)amino-2-oxoethoxylacetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Aminopentan-1-ol | HCID 75634 | — |
| 反応物 | 1,4-Dioxane-2,6-dione | HCID 78232 | — |
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 生成物 | 2-(5-Hydroxypentyl)amino-2-oxoethoxylacetic acid | HCID 20285862 | — |
反応手順
methanesulfonate by the following sequence of steps: (a) by reacting diglycolic anhydride and 5-aminopentanol to produce [2-(5-hydroxypentyl)amino-2-oxoethoxylacetic acid, (b) heating to cyclize the latter to obtain 4-(5-hydroxypentyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 5-(3,5-dioxomorpholino)pentyl methanesulfonate and (d) reacting the mesylate with 2-benzhydrylpiperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04256891 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-144787c7592949a3b5fbc70ae64e01f9 |
| 出典メモ | uspto-grants-1981_03 |