4-Amino-1-butanol → [2-(4-Hydroxybutyl]amino-2-oxoethoxy]acetic acid
反応式
CS([O-])(=O)=O.[C:6]1(=[O:13])[O:12][C:10](=[O:11])[CH2:9][O:8][CH2:7]1.[NH2:14][CH2:15][CH2:16][CH2:17][CH2:18][OH:19]>>[OH:19][CH2:18][CH2:17][CH2:16][CH2:15][NH:14][C:10](=[O:11])[CH2:9][O:8][CH2:7][C:6]([OH:12])=[O:13]参加物
4
実験手順
methanesulfonate by (a) reacting diglycolic anhydride and 4-aminobutanol to produce [2-(4-hydroxybutyl]amino-2-oxoethoxy]acetic acid, (b) heating to cyclize the latter to obtain 4-(4-hydroxybutyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 4-(3,5-dioxomorpholino)butyl methanesulfonate and (d) reacting the mesylate with 3[bis(4-butoxy-o-tolyl)methyl]piperidine.
出典と根拠
- ORDレコード
- ord-a2f55ef14d204f1bb066ba76871455d3
- 出典データセット
- uspto-grants-1981_03
- 特許番号
- US04256891
反応ノート
読み込み中…