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Ethanolamine → [2-(2-Hydroxyethylamino)-2-oxoethoxy]acetic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanolamine | HCID 700 | — |
| 反応物 | 1,4-Dioxane-2,6-dione | HCID 78232 | — |
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 生成物 | [2-(2-Hydroxyethylamino)-2-oxoethoxy]acetic acid | HCID 20558836 | — |
反応手順
methanesulfonate by (a) reacting diglycolic anhydride and 2-aminoethanol to produce [2-(2-hydroxyethylamino)-2-oxoethoxy]acetic acid, (b) heating to cyclixe the latter to obtain 4-(2-hydroxyethyl)-3,5-dioxomorpholine, (c) esterifying the latter with methanesulfonyl chloride to produce 2-(3,5-dioxomorpholino)ethyl methanesulfonate and (d) reacting the mesylate with piperidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04256891 |
| 出典データセット | uspto-grants-1981_03 |
| ORD ID | ord-69a71491bb6d4704857d6737cffbdffb |
| 出典メモ | uspto-grants-1981_03 |