Potassium Cyanide → Fenvalerate

HRID 1277529

反応式

HRID 1277529 の反応式
[C-:1]#[N:2].[K+].[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH:30]([CH3:32])[CH3:31])[C:12]([O:14][CH:15](Cl)[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=2)=[O:13])=[CH:7][CH:6]=1>CCOCC>[Cl:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([CH:30]([CH3:32])[CH3:31])[C:12]([O:14][CH:15]([C:1]#[N:2])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=2)=[O:13])=[CH:7][CH:6]=1

参加物

4

反応物 2

HCID 9032Potassium CyanideHCID 13061774alpha-Chloro-3-phenoxybenzyl 2-(p-chlorophenyl)-2-isopropyl-acetate

生成物 1

HCID 3347Fenvalerate

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

反応条件

温度
20 °C

実験手順

1.5 g of potassium cyanide were added to a mixture of 80 ml of acetonitrileand the solution obtained in Example 9 and the mixture was stirred at 20° C. for 72 hours. Ether was added to the mixture which was then filtered to remove insolubles. The filtrate was evaporated to dryness under reduced pressure and the residue was chromatographed over silica gel. Elution with a 95-5 cyclohexane-acetone mixture yielded 6.5 g of RS α-cyano-3-phenoxy-benzyl 2-(p-chlorophenyl)-2-isopropyl-acetate.

後処理

  1. filtrationwas then filtered
  2. customto remove insolubles
  3. customThe filtrate was evaporated to dryness under reduced pressure
  4. customthe residue was chromatographed over silica gel
  5. washElution with a 95-5 cyclohexane-acetone mixture

出典と根拠

ORDレコード
ord-c66f083d47984ddd9ac1ee8bcf23f5e8
出典データセット
uspto-grants-1981_07
特許番号
US04277617

関連ノート

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