Morpholine → 2-[4-(2-Acetamidoethyl)phenyl]acetic acid
反応式
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([O:14]CC)=[O:13])=[CH:7][CH:6]=1.N1CC[O:20][CH2:19][CH2:18]1.[S]>>[C:19]([NH:2][CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][C:8]([CH2:11][C:12]([OH:14])=[O:13])=[CH:9][CH:10]=1)(=[O:20])[CH3:18]参加物
4
実験手順
The ethyl 4-(2-aminoethyl)-phenylacetate hydrochloride used as starting material is prepared in the following manner: 4-(2-acetamidoethyl)-acetophenone is reacted with morpholine and sulfur to give the thiomorpholide of 4-(2-acetamidoethyl)-phenylacetic acid (m.p. 117°-118° C.). Subsequent alkaline saponification, followed by esterification with ethanolic hydrochloric acid, gives ethyl 4-(2-aminoethyl)-phenylacetate hydrochloride; m.p. 177°-178° C., after recrystallization from ethanol.
後処理
- customis prepared in the following manner
出典と根拠
- ORDレコード
- ord-423fcfdea0c94f6d938cd28e8597975d
- 出典データセット
- uspto-grants-1981_07
- 特許番号
- US04278680
反応ノート
読み込み中…