5-Chloro-2-methoxybenzoyl chloride → 4-[2-(5-Chloro-2-methoxybenzamido)-ethyl]-phenylacetic acid
反応式
[NH2:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:6][CH:5]=1.[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([O:26][CH3:27])=[C:21]([CH:25]=1)[C:22](Cl)=[O:23]>>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([O:26][CH3:27])=[C:21]([CH:25]=1)[C:22]([NH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:6][CH:5]=1)=[O:23].[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([O:26][CH3:27])=[C:21]([CH:25]=1)[C:22]([NH:1][CH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1)=[O:23]参加物
4
実験手順
In an analogous mannner, by the reaction of ethyl 4-(2-aminoethyl)-phenylacetate with 5-chloro-2-methoxybenzoyl chloride, there is obtained, via ethyl 4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenylacetate (oil), 4-[2-(5-chloro-2-methoxybenzamido)-ethyl]-phenylacetic acid; m.p. 127°-128° C., after recrystallization from 75% acetic acid.