Hydrochloric Acid → HCID 23451800、化合物

HRID 1277827ノート

反応式

HRID 1277827 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:18][C:19](=[O:23])OCC)[CH:5]=[C:6]([Cl:17])[C:7]=1[O:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[C:11]([Cl:16])[CH:10]=1.Cl>O>[CH3:19][N:18]1[CH:4]=[CH:3][N:18]([C:4]2[CH:5]=[C:6]([Cl:17])[C:7]([O:8][C:9]3[CH:10]=[C:11]([Cl:16])[CH:12]=[C:13]([Cl:15])[CH:14]=3)=[C:2]([Cl:1])[CH:3]=2)[C:19]1=[O:23]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 54304496Ethyl [3,5-dichloro-4-(3,5-dichlorophenoxy)phenyl]carbamate

生成物 1

HCID 23451800HCID 23451800、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Ethyl [3,5-dichloro-4-(3,5-dichlorophenoxy)phenyl]carbamate (0.02 mole), water (30 ml) and concentrated hydrochloric acid (3 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer and condenser. The mixture is refluxed for a period of about 30 minutes and then cooled and extracted with ethyl acetate. The extract is washed with dilute aqueous sodium bicarbonate, with two portions of water and is then dried. The ethyl acetate is removed by mild warming under reduced pressure to yield the desired product 1-methyl-3-[3,5-dichloro-4-(3,5-dichlorophenoxy) phenyl]-4-imidazolin-2-one.

後処理

  1. customfitted with a mechanical stirrer
  2. temperatureThe mixture is refluxed for a period of about 30 minutes
  3. temperaturecooled
  4. extractionextracted with ethyl acetate
  5. washThe extract is washed with dilute aqueous sodium bicarbonate, with two portions of water
  6. customis then dried
  7. customThe ethyl acetate is removed
  8. temperatureby mild warming under reduced pressure

出典と根拠

ORDレコード
ord-28393d8686f44ee0afa8517c0165eadf
出典データセット
uspto-grants-1981_07
特許番号
US04279637

反応ノート

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