2,2-Dimethoxyethylmethylamine → N-[4-(phenylmethyl)phenyl]-N'-(2,2-dimethoxyethyl)-N'-methylurea
反応式
[C:1]1([CH2:7][C:8]2[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:19])OCC)=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:20][O:21][CH:22]([O:26][CH3:27])[CH2:23][NH:24][CH3:25]>C1(C)C=CC=CC=1>[C:1]1([CH2:7][C:8]2[CH:9]=[CH:10][C:11]([NH:14][C:15]([N:24]([CH2:23][CH:22]([O:26][CH3:27])[O:21][CH3:20])[CH3:25])=[O:19])=[CH:12][CH:13]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1参加物
4
実験手順
Ethyl [4-(phenylmethyl)phenyl]carbamate (0.1 mole) and toluene (100 ml) are charged into a glass reaction vessel fitted with a mechanical stirrer, thermometer and condenser. N-(2,2-dimethoxyethyl)methanamine (0.15 mole) is added to the vessel and the mixture is refluxed for 16 hours. Solvent is then removed by mild warming under reduced pressure to yield the desired product N-[4-(phenylmethyl)phenyl]-N'-(2,2-dimethoxyethyl)-N'-methylurea.