3-(Methylamino)-1-benzoxepin-5(2H)-one → HCID 13446113、化合物

HRID 1277930ノート

反応式

HRID 1277930 の反応式
[CH3:1][NH:2][C:3]1[CH2:4][O:5][C:6]2[CH:14]=[CH:13][CH:12]=[CH:11][C:7]=2[C:8](=[O:10])[CH:9]=1.[H][H]>[Ni].C(O)C>[CH3:1][NH:2][CH:3]1[CH2:9][CH:8]([OH:10])[C:7]2[CH:11]=[CH:12][CH:13]=[CH:14][C:6]=2[O:5][CH2:4]1

参加物

5

反応物 2

HCID 134460473-(Methylamino)-1-benzoxepin-5(2H)-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 13446113HCID 13446113、化合物

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 702Ethanol溶媒

実験手順

18.8 g (0.1 mole) 3-methylamino-1-benzoxepin-5(2H)-one is stirred with 40 g Raney Nickel in 400 ml ethanol for five hours at an hydrogen pressure of 55 bar. Subsequently, the catalyst is filtered out, the solvent is distilled off and one obtains 7.7 g (40% of the theoretical yield) racemic-2,3,4,5-tetrahydro-3-methylamino-1-benzoxepin-5-ol as an oil. The compound can be further separated as described earlier and further identified.

後処理

  1. filtrationSubsequently, the catalyst is filtered out
  2. distillationthe solvent is distilled off
  3. customone obtains 7.7 g (40% of the

出典と根拠

ORDレコード
ord-b943c0d410744239aaebae8c2953c235
出典データセット
uspto-grants-1981_07
特許番号
US04279904

反応ノート

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