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1,1,1,2-Tetrachloro-2,2-difluoroethane → 3,3-Dimethyl-4,6,6,7-tetrachloro-7,7-difluoroenanthic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,1,1,2-Tetrachloro-2,2-difluoroethane | HCID 6426 | — |
| 反応物 | Benzoin | HCID 8400 | — |
| 反応物 | Dimethylamine, hydrochloride | HCID 10473 | — |
| 反応物 | Methyl 3,3-dimethyl-4-pentenoate | HCID 114129 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 3,3-Dimethyl-4,6,6,7-tetrachloro-7,7-difluoroenanthic acid methyl ester | HCID 15575036 | — |
反応手順
37.5 g of 3,3-dimethyl-4-pentenoic acid methyl ester, 102 g of 1,1,1,2-tetrachloro-2,2-difluoroethane, 22 g of acetonitrile, 325 mg of FeCl3.6H2O, 255 mg of benzoin and 200 mg of dimethylamine hydrochloride were heated to 100°-120° C. in a 250 ml VA autoclave under 6 bars of nitrogen for 7 hours. Distillation of the mixture gave 3,3-dimethyl-4,6,6,7-tetrachloro-7,7-difluoroenanthic acid methyl ester of boiling point 129°-134° C./0.7-0.9 m bar. Refractive index: nD20 =1.4680. ##STR8##
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04279923 |
| 出典データセット | uspto-grants-1981_07 |
| ORD ID | ord-8d9c87fbabdc48cfa957e9862b8938dc |
| 出典メモ | uspto-grants-1981_07 |