5-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamine → HCID 178504070、化合物

HRID 1277999ノート

反応式

HRID 1277999 の反応式
[NH2:1][CH2:2][CH2:3][S:4][CH2:5][C:6]1[O:10][C:9]([CH2:11][N:12]([CH3:14])[CH3:13])=[CH:8][CH:7]=1.[CH3:15][S:16]([N:19]=[C:20](SC)[S:21][CH3:22])(=[O:18])=[O:17]>C(OCC)(=O)C>[CH3:13][N:12]([CH2:11][C:9]1[O:10][C:6]([CH2:5][S:4][CH2:3][CH2:2][NH:1][C:20]([S:21][CH3:22])=[N:19][S:16]([CH3:15])(=[O:18])=[O:17])=[CH:7][CH:8]=1)[CH3:14]

参加物

4

反応物 2

HCID 1622035-(((2-Aminoethyl)thio)methyl)-N,N-dimethyl-2-furanmethanamineHCID 13449843N-[bis(methylsulfanyl)methylidene]methanesulfonamide

生成物 1

HCID 178504070HCID 178504070、化合物収率 79%

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 5-[[(2-aminoethyl)thio]methyl]-N,N-dimethyl-furanmethanamine (2.97 g) and methylsulphonylcarbonimidodithioic acid, dimethyl ester (4.0 g) in ethyl acetate (250 ml) was refluxed for 18 hours. The mixture was washed with acetic acid (0.126 ml) in water (20 ml) three times, the aqueous extracts combined and the pH adjusted to 9 with 8% aqueous potassium carbonate. The oily suspension was extracted with ethyl acetate (3×125 ml), the combined extracts dried (magnesium sulphate) and evaporated to dryness to give the title compound (4 g) as a yellow oil.

後処理

  1. temperaturewas refluxed for 18 hours
  2. washThe mixture was washed with acetic acid (0.126 ml) in water (20 ml) three times
  3. extractionThe oily suspension was extracted with ethyl acetate (3×125 ml)
  4. dry with materialthe combined extracts dried (magnesium sulphate)
  5. customevaporated to dryness

出典と根拠

ORDレコード
ord-82202389d44b45cbbfd80cadcd845969
出典データセット
uspto-grants-1981_07
特許番号
US04279911

反応ノート

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