Ethyl 4-nitrophenylacetate → 2-(alpha-Ethoxycarbonyl-4-nitrobenzylidene)-1-methylpyrrolidine

HRID 1278043

反応式

HRID 1278043 の反応式
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)[CH3:2].C(O[C:19]1(OCC)[CH2:23][CH2:22][CH2:21][N:20]1[CH3:24])C>C1C=CC=CC=1>[CH2:1]([O:3][C:4]([C:5](=[C:19]1[CH2:23][CH2:22][CH2:21][N:20]1[CH3:24])[C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-:14])=[O:13])=[CH:8][CH:7]=1)=[O:15])[CH3:2]

参加物

4

反応物 2

HCID 79517Ethyl 4-nitrophenylacetateHCID 2973082,2-Diethoxy-1-methylpyrrolidine

生成物 1

HCID 545197932-(alpha-Ethoxycarbonyl-4-nitrobenzylidene)-1-methylpyrrolidine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

Boil 50 g of 4-nitrophenylacetic acid ethyl ester and 41.4 g of 2,2-diethoxy-1-methylpyrrolidine under reflux for 3 hours in 250 ml of benzene. Distil off the benzene before recrystallizing the resulting residue from diethyl ether/petroleum ether to obtain the title compound at a yield of 52.6 g (77% of theory) in the form of red crystals of m.p. 82° to 83°.

後処理

  1. customDistil off the benzene
  2. custombefore recrystallizing the resulting residue from diethyl ether/petroleum ether

出典と根拠

ORDレコード
ord-be52418171e1411985dd9643aa0b5774
出典データセット
uspto-grants-1981_07
特許番号
US04279918

関連ノート

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