N,O-Dimethylhydroxylamine → N'-[4-(2-naphthyloxy)phenyl]-N-methoxy-N-methylurea

HRID 1278162ノート

反応式

HRID 1278162 の反応式
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]=[C:19]=[O:20])=[CH:14][CH:13]=1.[CH3:21][NH:22][O:23][CH3:24]>C1C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([NH:18][C:19](=[O:20])[N:22]([O:23][CH3:24])[CH3:21])=[CH:14][CH:13]=1

参加物

4

反応物 2

HCID 14232N,O-DimethylhydroxylamineHCID 127740664-(2-Naphthyloxy)phenyl isocyanate

生成物 1

HCID 12893343N'-[4-(2-naphthyloxy)phenyl]-N-methoxy-N-methylurea収率 87.3%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

Thirteen grams of 4-(2-naphthyloxy)phenyl isocyanate were dissolved in 100 ml of benzene, and a solution of 4 g of N,O-dimethylhydroxylamine in 50 ml of benzene was added dropwise thereto at a temperature below 30° C. The reaction mixture was allowed to stand at room temperature for 30 minutes, and the solvent was then removed under reduced pressure. The residue was recrystallized from ethanol to obtain 14 g of N'-[4-(2-naphthyloxy)phenyl]-N-methoxy-N-methylurea as white needles. M.P., 102°-103° C.

後処理

  1. customat a temperature below 30° C
  2. customthe solvent was then removed under reduced pressure
  3. customThe residue was recrystallized from ethanol

出典と根拠

ORDレコード
ord-00fa8abd9f3042a093cef9b96ed85e8a
出典データセット
uspto-grants-1981_07
特許番号
US04280835

反応ノート

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