Water → 3-(Trifluoromethyl)-4-isopropoxynitrobenzene

HRID 127817

反応式

HRID 127817 の反応式
[CH3:1][CH:2]([CH3:4])[O-:3].[Na+].Cl[C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:8]=1[C:16]([F:19])([F:18])[F:17].O>CS(C)=O>[CH:2]([O:3][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][C:8]=1[C:16]([F:17])([F:18])[F:19])([CH3:4])[CH3:1]

参加物

5

反応物 3

HCID 962WaterHCID 612132-Chloro-5-nitrobenzotrifluorideHCID 109204432-Propanol, sodium salt (1:1)

生成物 1

HCID 105385593-(Trifluoromethyl)-4-isopropoxynitrobenzene

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒2 回

実験手順

A solution of 41 g of sodium isopropoxide in 300 ml of dimethyl sulfoxide was added drop-by-drop to a chilled (5° C.) solution of 118 g of 2-chloro-5-nitrobenzotrifluoride in 100 ml of dimethyl sulfoxide. The resulting mixture was stirred at room temperature for one hour, poured into water, and the resulting mixture was extracted with ether. The extract was washed with water, dried, and the solvent was evaporated. The liquid residue was taken up in hexane and the solution was chilled to give a solid, which on recrystallization from hexane gave 2-isopropoxy-5-nitrobenzotrifluoride (2A), as a white crystalline solid, mp: 34°-36° C.

後処理

  1. extractionthe resulting mixture was extracted with ether
  2. washThe extract was washed with water
  3. customdried
  4. customthe solvent was evaporated
  5. temperaturethe solution was chilled
  6. customto give a solid, which
  7. customon recrystallization from hexane

出典と根拠

ORDレコード
ord-02ae50cfe1df482a904e6d0c58b914cb
出典データセット
uspto-grants-1981_03
特許番号
US04257805

関連ノート

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