2-Amino-5-(trifluoromethyl)pyridine → 1-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

HRID 1278179ノート

反応式

HRID 1278179 の反応式
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([NH2:9])=[N:7][CH:8]=1.[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([N:17]=[C:18]=[O:19])=[O:16]>>[Cl:12][C:13]1[CH:23]=[CH:22][CH:21]=[C:20]([F:24])[C:14]=1[C:15]([NH:17][C:18]([NH:9][C:6]1[CH:5]=[CH:4][C:3]([C:2]([F:1])([F:10])[F:11])=[CH:8][N:7]=1)=[O:19])=[O:16]

参加物

3

反応物 2

HCID 7358622-Amino-5-(trifluoromethyl)pyridineHCID 130517312-Chloro-6-fluorobenzoyl isocyanate

生成物 1

HCID 205331381-(2-Chloro-6-fluorobenzoyl)-3-(5-trifluoromethyl-2-pyridinyl)urea

実験手順

A portion of 5-trifluoromethyl-2-aminopyridine is reacted with 2-chloro-6-fluorobenzoyl isocyanate as described in Example 1. The reaction mixture is evaporated under vacuum and the product is recrystallized to obtain the product named above.

後処理

  1. customThe reaction mixture is evaporated under vacuum
  2. customthe product is recrystallized
  3. customto obtain the product

出典と根拠

ORDレコード
ord-e5930e012c074200becefce690fb7738
出典データセット
uspto-grants-1981_07
特許番号
US04281003

反応ノート

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